Publications: A∙WOL I: Anti Symbiotic Treatment of Filariasis

Johnston, Kelly, Wu, B., Guimaraes, A., Ford, Louise, Ambrose, Pauline, Slatko, B. E. and Taylor, Mark (2008) 'Globomycin: A New Class of Drug with Efficacy against Wolbachia and Filarial Nematodes'. American Journal of Tropical Medicine and Hygiene, Vol 79, Issue 6 Sup., p. 128

Turner JD, Tendongfor N, Esum M, Johnston KL, Langley RS, Ford L, Faragher B, Specht S, Mand S, Hoerauf A, Enyong P, Wanji S, Taylor MJ. (2010) Macrofilaricidal activity after doxycycline only treatment of Onchocerca volvulus in an area of Loa loa co-endemicity: a randomized controlled tria(link is external)l. PLoS Neglected Tropical Diseases, 4 (4): e660

Landmann F, Foster JM, Slatko B, Sullivan W. (2010) Asymmetric Wolbachia segregation during early Brugia malayi embryogenesis determines its distribution in adult host tissues(link is external). PLoS Neglected Tropical Diseases, 4(7): e758

Strübing U, Lucius R, Hoerauf A, Pfarr KM. (2010) Mitochondrial genes for heme-dependent respiratory chain complexes are up-regulated after depletion of Wolbachia from filarial nematodes(link is external). International Journal for Parasitology, 40(10): 1193-202.

Johnston KL, Wu B, Guimarães A, Ford L, Slatko BE, Taylor MJ. (2010) Lipoprotein biosynthesis as a target for anti-Wolbachia treatment of filarial nematodes(link is external). Parasites and Vectors. 3:99

Wanji S, Tendongfor N, Nji T, Esum M, Che JN, Nkwescheu A, Alassa F, Kamnang G, Enyong PA, Taylor MJ, Hoerauf A and Taylor DW (2009). Community-directed delivery of doxycycline for the treatment of onchocerciasis in areas of co-endemicity with loiasis in Cameroon(link is external). Parasites and Vectors 2: 39.

Turner JD, Langley RS, Johnston KL, Gentil K, Ford L, Wu B, Graham M, Sharpley F, Slatko B, Pearlman E andTaylor MJ (2009). Wolbachia lipoprotein stimulates innate and adaptive immunity through Toll-like receptors 2 and 6 to induce disease manifestations of filariasis(link is external). Journal of Biological Chemistry 284: 22364-22378.

Taylor MJ, Awadzi K, Basáñez MG, Biritwum N, Boakye D, Boatin B, Bockarie M, Churcher TS, Debrah A, Edwards G, Hoerauf A, Mand S, Matthews G, Osei-Atweneboana M, Prichard RK, Wanji S and Adjei O (2009). Onchocerciasis Control: Vision for the Future from a Ghanian perspective(link is external). Parasites and Vectors 2: 7.

Foster J, Kumar S, Ford L, Johnston KL, Ben R, Graeff-Teixeira C and Taylor MJ (2008). Absence of Wolbachia endobacteria in the non-filariid nematodes Angiostrongylus cantonensis and A. costaricensis. Parasites and Vectors1: 31.(link is external)

Tamarozzi F, Tendongfor N, Enyong PA, Esum M, Faragher B, Wanji S, Taylor MJ.
Parasit Vectors. 2012 Mar 20;5:53. doi: 10.1186/1756-3305-5-53. Long term impact of large scale community-directed delivery of doxycycline for the treatment of onchocerciasis.(link is external)

Landmann F, Voronin D, Sullivan W, Taylor MJ. PLoS Pathog. 2011 Nov;7(11):e1002351. doi: 10.1371/journal.ppat.1002351. Epub 2011 Nov 3. Anti-filarial activity of antibiotic therapy is due to extensive apoptosis after Wolbachia depletion from filarial nematodes.(link is external)

Debrah AY, Mand S, Marfo-Debrekyei Y, Batsa L, Pfarr K, Lawson B, Taylor M, Adjei O, Hoerauf A.
Am J Trop Med Hyg. 2009 Jun;80(6):956-63. Reduction in levels of plasma vascular endothelial growth factor-A and improvement in hydrocele patients by targeting endosymbiotic Wolbachia sp. in Wuchereria bancrofti with doxycycline.(link is external)

Holman AG, Davis PJ, Foster JM, Carlow CK, Kumar S. BMC Microbiol. 2009 Nov 28;9:243. doi: 10.1186/1471-2180-9-243. Computational prediction of essential genes in an unculturable endosymbiotic bacterium, Wolbachia of Brugia malayi.(link is external)(link is external)

Voronin D, Cook DA, Steven A, Taylor MJ.
Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):E1638-46. doi: 10.1073/pnas.1203519109. Epub 2012 May 29. Autophagy regulates Wolbachia populations across diverse symbiotic associations(link is external).(link is external)

Schiefer A1, Schmitz A, Schäberle TF, Specht S, Lämmer C, Johnston KL, Vassylyev DG, König GM, Hoerauf A, Pfarr KJ Infect Dis. 2012 Jul 15;206(2):249-57. doi: 10.1093/infdis/jis341. Epub 2012 May 14. Corallopyronin A specifically targets and depletes essential obligate Wolbachia endobacteria from filarial nematodes in vivo.(link is external)(link is external)


Slatko BE, Taylor MJ, Foster JM. (2010) The Wolbachia endosymbiont as an anti-filarial nematode target.(link is external) Symbiosis, 51(1): 55-65.(link is external)

Taylor MJ, Hoerauf A, Bockarie M. (2010) Lymphatic filariasis and onchocerciasis(link is external). Lancet, 2; 376(9747):1175-85.(link is external)

Bockarie MJ1, Taylor MJ, Gyapong JO. Expert Rev Anti Infect Ther. 2009 Jun;7(5):595-605. doi: 10.1586/eri.09.36. Current practices in the management of lymphatic filariasis.(link is external)(link is external)

Tamarozzi F, Halliday A, Gentil K, Hoerauf A, Pearlman E, Taylor MJ.Clin Microbiol Rev. 2011 Jul;24(3):459-68. doi: 10.1128/CMR.00057-10. Onchocerciasis: the role of Wolbachia bacterial endosymbionts in parasite biology, disease pathogenesis, and treatment.