Joseph D. Turner,1, Raman Sharma,1, Ghaith Al Jayoussi, Hayley E. Tyrer, Joanne Gamble, Laura Hayward, Richard S. Priestley, Emma A. Murphy, Jill Davies, David Waterhouse, Darren A. N. Cook, Rachel H. Clare, Andrew Cassidy, Andrew Steven, Kelly L. Johnston, John McCall, Louise Ford, Janet Hemingway,2, Stephen A. Ward, and Mark J. Taylor PNAS October 2017 doi: 10.1073/pnas.1710845114 Albendazole and antibiotics synergize to deliver short-course anti-Wolbachia curative treatments in preclinical models of filariasis
Kelly L. Johnston1,*, Darren A. N. Cook1,*, Neil G. Berry2,*, W. David Hong2,*, Rachel H. Clare1, Megan Goddard1, Louise Ford1, Gemma L. Nixon2, Paul M. O’Neill2, Stephen A. Ward1 and Mark J. Taylor1,† Science Advances 27 Sep 2017: Vol. 3, no. 9, eaao1551 DOI: 10.1126/sciadv.aao1551 Identification and prioritization of novel anti-Wolbachia chemotypes from screening a 10,000-compound diversity library
Ghaith Aljayyoussi, Hayley E. Tyrer, Louise Ford, Hanna Sjoberg, Nicolas Pionnier, David Waterhouse, Jill Davies, Joanne Gamble, Haelly Metugene, Darren A. N. Cook, Andrew Steven, Raman Sharma, Ana F. Guimaraes, Rachel H. Clare, Andrew Cassidy, Kelly L. Johnston, Laura Myhill, Laura Hayward, Samuel Wanji, Joseph D. Turner, Mark J. Taylor & Stephen A. Ward. Scientific Reports 7, Article number: 210 (2017) Short-Course, High-Dose Rifampicin Achieves Wolbachia Depletion Predictive of Curative Outcomes in Preclinical Models of Lymphatic Filariasis and Onchocerciasis
Ute Klarmann-Schulz , Sabine Specht , Alexander Yaw Debrah , Linda Batsa, Nana Kwame Ayisi-Boateng, Jubin Osei-Mensah, Yusif Mubarik, Peter Konadu, Arcangelo Ricchiuto, Rolf Fimmers, Sandra Arriens, Bettina Dubben, Louise Ford, Mark Taylor, Achim Hoerauf. (2017) Comparison of Doxycycline, Minocycline, Doxycycline plus Albendazole and Albendazole Alone in Their Efficacy against Onchocerciasis in a Randomized, Open-Label, Pilot Trial(link is external)
Gleave, Katherine, Cook, Darren, Taylor, Mark J. and Reimer, Lisa J. (2016) 'Filarial infection influences mosquito behaviour and fecundity'(link is external). Scientific Reports, Vol 6, Issue 36319.
Tamarozzi, Francesca, Turner, Joseph, Pionnier, Nicolas, Midgley, Angela, Guimaraes, Ana, Johnston, Kelly, Edwards, Steven W and Taylor, Mark (2016) 'Wolbachia endosymbionts induce neutrophil extracellular trap formation in human onchocerciasis'(link is external). Scientific Reports, Vol 6, p. 35559.
Sharma R, Al Jayoussi G, Tyrer HE, Gamble J, Hayward L, Guimaraes AF, Davies J, Waterhouse D, Cook DA, Myhill LJ, Clare RH, Cassidy A, Steven A, Johnston KL, Ford L, Turner JD, Ward SA, Taylor MJ. Sci Rep. 2016 Mar 21;6:23458. doi: 10.1038/srep23458. Minocycline as a re-purposed anti-Wolbachia macrofilaricide: superiority compared with doxycycline regimens in a murine infection model of human lymphatic filariasis.(link is external)
Halliday A, Turner JD, Guimarães A, Bates PA, Taylor MJ Parasit Vectors. 2016 Feb 20;9:96. doi: 10.1186/s13071-016-1381-0. The TLR2/6 ligand PAM2CSK4 is a Th2 polarizing adjuvant in Leishmania major and Brugia malayi murine vaccine models.(link is external)
Frempong KK, Walker M, Cheke RA, Tetevi EJ, Gyan ET, Owusu EO, Wilson MD, Boakye DA, Taylor MJ, Biritwum NK, Osei-Atweneboana M, Basáñez MG. Clin Infect Dis. 2016 Jun 1;62(11):1338-47. doi: 10.1093/cid/ciw144. Epub 2016 Mar 21. Does Increasing Treatment Frequency Address Suboptimal Responses to Ivermectin for the Control and Elimination of River Blindness?