Publications: A·WOL II: Discovery & Development of Macrofilaricidal Drugs & Regimens

Sarkies, Peter, Selkirk, Murray E., Jones, John T., Blok, Vivian, Boothby, Thomas, Goldstein, Bob, Hanelt, Ben, Ardila-Garcia, Alex, Fast, Naomi M., Schiffer, Phillip M., Kraus, Christopher, Taylor, Mark, Koutsovoulos, Georgios, Blaxter, Mark L. and Miska, Eric A. (2015) 'Ancient and Novel Small RNA Pathways Compensate for the Loss of piRNAs in Multiple Independent Nematode Lineages'.(link is external) PLoS Biology, Vol 13, Issue 2, e1002061.

Molyneux DH, Ward SA. (2015) Reflections on the Nobel Prize for Medicine 2015 - The Public Health Legacy and Impact of Avermectin and Artemisinin.(link is external) Trends Parasitol. 2015 Nov 6. pii: S1471-4922(15)00231-7. doi: 10.1016/

Lisa J Reimer, Emily R Adams, Mark JI Paine, Hilary Ranson, Marlize Coleman, Edward K Thomsen, Eleanor E MacPherson, T Deirdre Hollingsworth, Louise A Kelly-Hope, Moses J Bockarie, Louise Ford, Robert A Harrison, J Russell Stothard, Mark J Taylor, Nicholas Hamon and Stephen J Torr. Fit for purpose: do we have the right tools to sustain NTD elimination?(link is external) BMC Proceedings 2015, 9(Suppl 10):S5 doi:10.1186/1753-6561-9-S10-S5 Published: 18 December 2015.

Walker M, Specht S, Churcher TS, Hoerauf A, Taylor MJ, Basáñez MG. (2015) Therapeutic efficacy and macrofilaricidal activity of doxycycline for the treatment of river blindness.(link is external) Clin Infect Dis. 2015 60(8):1199-207.

Clare RH, Cook DA, Johnston KL, Ford L, Ward SA, Taylor MJ. (2015) Development and validation of a high-throughput anti-Wolbachia whole-cell screen: a route to macrofilaricidal drugs against onchocerciasis and lymphatic filariasis.(link is external) J Biomol Screen. 2015 20(1):64-9.

Vollmer J, Schiefer A, Schneider T, Jülicher K, Johnston KL, Taylor MJ, Sahl HG, Hoerauf A, Pfarr K. Requirement of lipid II biosynthesis for cell division in cell wall-less Wolbachia, endobacteria of arthropods and filarial nematodes(link is external). Int J Med Microbiol. 2013 Apr;303(3):140-9.

Ioannidis P, Johnston KL, Riley DR, Kumar N, White JR, Olarte KT, Ott S, Tallon LJ, Foster JM, Taylor MJ, Dunning Hotopp JC. BMC Genomics. 2013 Sep 22;14:639. doi: 10.1186/1471-2164-14-639. Extensively duplicated and transcriptionally active recent lateral gene transfer from a bacterial Wolbachia endosymbiont to its host filarial nematode Brugia malayi(link is external)

Foster JM, Landmann F, Ford L, Johnston KL, Elsasser SC, Schulte-Hostedde AI, Taylor MJ, Slatko BE. Parasit Vectors. 2014 Mar 31;7:140. doi: 10.1186/1756-3305-7-140. Absence of Wolbachia endobacteria in the human parasitic nematode Dracunculus medinensis and two related Dracunculus species infecting wildlife.(link is external)

Tamarozzi F, Wright HL, Johnston KL, Edwards SW, Turner JD, Taylor MJ. Parasite Immunol. 2014 Oct;36(10):494-502. doi: 10.1111/pim.12122. Human filarial Wolbachia lipopeptide directly activates human neutrophils in vitro.(link is external)

Voronin D, Guimarães AF, Molyneux GR, Johnston KL, Ford L, Taylor MJ Parasit Vectors. 2014 Oct 6;7:462. doi: 10.1186/s13071-014-0462-1. Wolbachia lipoproteins: abundance, localisation and serology of Wolbachia peptidoglycan associated lipoprotein and the Type IV Secretion System component, VirB6 from Brugia malayi and Aedes albopictus.(link is external)

Johnston KL, Ford L, Umareddy I, Townson S, Specht S, Pfarr K, Hoerauf A, Altmeyer R, Taylor MJ Int J Parasitol Drugs Drug Resist. 2014 Sep 16;4(3):278-86. doi: 10.1016/j.ijpddr.2014.09.001. eCollection 2014. Repurposing of approved drugs from the human pharmacopoeia to target Wolbachia endosymbionts of onchocerciasis and lymphatic filariasis.(link is external)

Halliday A, Guimaraes AF, Tyrer HE, Metuge HM, Patrick CN, Arnaud KO Kwenti TD, Forsbrook G, Steven A, Cook D, Enyong P, Wanji S, Taylor MJ, Turner JD. Parasit Vectors. 2014 Oct 24;7:472. doi: 10.1186/s13071-014-0472-z. A murine macrofilaricide pre-clinical screening model for onchocerciasis and lymphatic filariasis.(link is external)

Landmann F, Bain O, Martin C, Uni S, Taylor MJ, Sullivan W Biol Open. 2012 Jun 15;1(6):536-47. doi: 10.1242/bio.2012737. Epub 2012 Apr 18. Both asymmetric mitotic segregation and cell-to-cell invasion are required for stable germline transmission of Wolbachia in filarial nematodes.(link is external)

Schroeder JH, Simbi BH, Ford L, Cole SR, Taylor MJ, Lawson C, Lawrence RA. PLoS Negl Trop Dis. 2012;6(11):e1914. doi: 10.1371/journal.pntd.0001914. Epub 2012 Nov 29. Live Brugia malayi microfilariae inhibit transendothelial migration of neutrophils and monocytes(link is external).

Wu B, Novelli J, Jiang D, Dailey HA, Landmann F, Ford L, Taylor MJ, Carlow CK, Kumar S, Foster JM, Slatko BE. Proc Natl Acad Sci U S A. 2013 May 7;110(19):7748-53. doi: 10.1073/pnas.1304049110. Epub 2013 Apr 22. Interdomain lateral gene transfer of an essential ferrochelatase gene in human parasitic nematodes(link is external).


Taylor MJ, Voronin D, Johnston KL, Ford L. Wolbachia filarial interactions. Cell Microbiol.(link is external) 2013 Apr;15(4):520-6. doi: 10.1111/cmi.12084. Epub 2012 Dec 24.

Mark J. Taylor, Louise Ford, Achim Hoerauf, Ken Pfarr, Jeremy M. Foster, Sanjay Kumar and Barton E. Slatko. 2012. Drugs and Targets to Perturb the Symbiosis of Wolbachia and Filarial Nematodes.(link is external) In Parasitic Helminths: Targets, Screens, Drugs, and Vaccines

Johnston KL, Ford L, Taylor MJ. J Biomol Screen. 2014 Mar;19(3):335-43. doi: 10.1177/1087057113511270. Epub 2013 Nov 15. Overcoming the challenges of drug discovery for neglected tropical diseases: the A·WOL experience.(link is external)

Taylor MJ, Hoerauf A, Townson S, Slatko BE, Ward SA. Parasitology. 2014 Jan;141(1):119-27. doi: 10.1017/S0031182013001108. Epub 2013 Jul 18. Anti-Wolbachia drug discovery and development: safe macrofilaricides for onchocerciasis and lymphatic filariasis.